Tadalafil
Tadalafil yog ib qho kev xaiv phosphodiesterase -5 inhibitor uas yog siv los kho erectile kawg (ED), pulmonary arterial hypertension (PAH), thiab benign prostatic hypertrophy. Nws tau pom zoo thawj zaug hauv xyoo 2003 los ntawm FDA rau kev siv hauv ED thiab tom qab xyoo 2009 rau PAH. Nyob rau hauv sib piv rau lwm yam PDE5 inhibitors zoo li [sildenafil], tadalafil muaj ntau dua selectivity rau PDE5 thiab ib nrab-lub neej ntev uas tau ua nws ib tug ntau haum xaiv rau mob ib hnub ib zaug noj nyob rau hauv kev kho mob ntawm PAH.
Cov ntaub ntawv khoom ntiag tug
| 1 | Tshuaj npe | Tadalafil |
| 2 | CAS Nr | 171596-29-5 |
| 3 | Formula | C22H19N3O4 |
| 4 | Molar loj | 389,411g ,ua−1 |
| 5 | Exact Mass | 389.13755610 g / mol |
| 6 | Qhov ntom | 1.5 ± 0.1 g/cm3 |
| 7 | Boiling point | 679.1 ± 55. 0 degree ntawm 760 mmHg |
| 8 | Melting point | 298-300ºC |
| 9 | Flash point | 364.5 ± 31.5 degree |
| 10 | PSA | 74.87 |
| 11 | LogP | 1.43 |
| 12 | Qhov tsos: | tawm-dawb crystal zoo li khoom |
| 13 | Vapor siab | {{0}}.0 ± 2.1 mmHg ntawm 25 degree |
| 14 | Refractive Index | 1.758 |
| 15 | Cia tej yam kev mob | Hygroscopic, -20 degree Lub Freezer, Nyob rau hauv Inert Atmosphere |
| 16 | Solubility: | Dej insoluble; soluble nyob rau hauv: dimethylformamide; me ntsis soluble: ethanol, dichloromethane |
Daim ntawv thov
Tadalafil yog siv los kho erectile kawg, benign prostatic hyperplasia, thiab pulmonary arterial hypertension. Hauv Teb Chaws Asmeskas, tadalafil (raws li Cialis) yog qhia rau kev kho mob ntawm erectile kawg thiab cov tsos mob thiab cov tsos mob ntawm benign prostatic hyperplasia; thiab (raws li Adcirca) rau kev kho mob pulmonary arterial hypertension los txhim kho kev muaj peev xwm.
Benign prostatic hypertrophy
Ib qho tshuaj ntsuam xyuas meta pom tau tias tadalafil yog ib qho kev kho mob zoo rau cov tsos mob ntawm cov zis qis vim yog prostatic hyperplasia thiab cov kev kho mob zoo li no muaj qhov cuam tshuam tsis zoo. Tadalafil yog FDA pom zoo rau cov txiv neej ua kev kho mob thiab tiv thaiv cov tsos mob ntawm benign prostatic. hypertrophy, xws li urinary ceev, hesitancy, qaug zog kwj, dribbling, thiab incontinence. Tadalafil tau pom tias muaj cov txiaj ntsig zoo sib xws rau cov tsos mob ntawm cov zis qis raws li cov tshuaj tamsulosin feem ntau.
Pulmonary arterial hypertension
Tadalafil tau txais kev pom zoo hauv Tebchaws Meskas, Canada, thiab Nyij Pooj los txhim kho kev tawm dag zog hauv cov neeg mob ntshav siab.
Cim npe nrov: Tuam Tshoj tadalafil manufacturers, lwm tus neeg, Hoobkas
